Autophagy in cancer( colonic adenoma and adenocarcinoma) Literature review

Autophagy in cancer( colonic adenoma and adenocarcinoma) - Literature review Example From this point, it is evident that the microvasculature of the tumor tissue is actually structurally and functionally deficient and hence is unable to provide blood supply that is prerequisite for appropriate tissue growth. To support this fact, there is evidence that some tumors, like the pancreas cancers are actually hypovascular (Sato et al, 2007). These conditions contribute to hyponutrient state of the tumor. However, for hypoproliferation, excess nutrient supply is mandatory and hence tumor cells are likely to use alternative source of energy and nutrients or some alternative metabolic process for the purpose. One such metabolic process is autophagy. There is evidence that some cancers, like the colon cancer, are resistant to nutrition depletion state and continue to thrive because of this metabolic process (Sato et al, 2007). Autophagy is a catabolic process that is conserved in which the organelles of the cells are self-digested. The first step in autophagy is development of isolation membrane, a lipid bilayer structure. This membrane sequesters various materials of the cytoplasm like the organelles to form autophagosomes. This step involves activation of LC3, a mammalian homologue of yeast ATG8 through an ubiquitination-like reaction that is regulated by ATG3 and 7. During activation, the proform of LC3 is cleaved into LC3-I which is soluble unlike the proform. This is then further modified into LC3-II which is membrane-bound form. This form is finally recruited by the autophagosomes which engulf the organelles (Rosenfeldt and Ryan, 2009). The engulfed organelles further fuse with the lysosomes and then mature into autolysosomes. This step also causes autodigestion and diminision of LC3 and also various other components of autophagosome. Thus autophagy has an important role to play in the provision of nutrition to cells during shortage of external supply of nutrition. Following autodigestion, aminoacids are released from the organelles and they are th e alternative sources of energy to the proliferative and nutrient deficient cells. Though, theoretically, this explanation seems logical with reference to nutrition supply to cancer cells in unfavorable environment, several controversial arguments have arisen in this regard. Some researchers are of the opinion that autophagic machinery may not be activated in cancer tissue contexts (Sato et al, 2007). However, there is enough evidence to point the role of autophagy in the pathogenesis of colon cancers. In this literature review the role of autophagy in the proliferation and thriving of colon cancers will be discussed through suitable literature review. Pathogenesis of colon cancer Cancer of the colon (and rectum) is the third most common cancer in men and women. It has been estimated that 940,000 new cases of colorectal cancer and nearly 500,000 deaths are occur worldwide each year (El- Deiry, 2006). The frequency is same both in men and women. The risk of the disease increases afte r 40 years of age (El- Deiry, 2006). Colon cancer (colorectal cancer) is almost always adenocarcinoma. The most common predisposing condition leading to adenocarcinoma is adenomatous polyps. Alterations in the adenomatous polyposis or APC gene as a result of mutations is the beginning point of development of the cancer. This gene is mutated in individuals affected by familial

THE IMPACT OF PLANNING POLICIES FOR THE OLYMPIC GAMES WILL OPTIMIZE Essay

THE IMPACT OF PLANNING POLICIES FOR THE OLYMPIC GAMES WILL OPTIMIZE THE SOCIO-CULTURAL IMPACTS OF TOURISM FOR LONDON RESIDENTS - Essay Example Tourism as a manifestation of leisure presupposes a socioeconomic milieu in which money and time-away-from-work can be accumulated to be spent at will. Tourism as a form of mobility implies that culturally sanctioned reasons exist for leaving home to travel. Tourism as an organized industry, catering to a clientele who have time and money and want to spend them, pleasurably, in leisured mobility or migration. Tourism in the modal sense is one of a range of choices, or styles, of vacation or recreation. Tourist visits are ritualized breaks in routine that define and relieve the ordinary. POSITIVE SOCIO-CULTURAL EFFECTS OF THE LONDON 2012 OLYMPIC GAMES The first positive socio-cultural impact is that tourism is a force for peace. The tourists who will travel to London for the Olympic Games will be won over by the residents of London. The close interaction with people from different countries will develop mutual sympathy and understanding and reduce their racial prejudices. This close interaction and cooperation will lead to world understanding and world peace. The second positive socio-cultural impact is that the London Games of 2012 will strengthen local communities. The local residents will be involved as volunteers and the celebration of festivals will lead to cultural rejuvenation. The tourist interest for festivals will enrich the cultural exchange between the participants. Moreover, the thousands of jobs created by tourism can act as a vital incentive to reduce emigration from rural areas. The third positive socio-cultural impact is that the facilities developed for the tourism-related Olympic Games benefit local residents d uring and after the Games.

How can Economic Value Added (EVA) statements be used to improve Essay - 2

How can Economic Value Added (EVA) statements be used to improve financial statement reporting, results, and success What are some problems found with EVA - Essay Example Making financial decisions only based on accounting data is a traditional way that can be misleading for the financial managers to make bad decisions. EVA measures are useful for the business to make decisions that can help the business to grow and help in making future ones. EVA creates the ‘value’ in the business decisions and financial management. The EVA calculations and statements are drawn by evaluating the value that has been added to the company. It shows how much the business has grown in terms of the worth it has. There are many factors that the EVA statements take into consideration to make sure that all the relevant data is considered when measuring the value of the business. It calculates how much the growth of the business is and how much has been invested for that growth. It takes out the net benefit that the business has gained and in regard of that cost that has been put in for that benefit (Grant, 2003). The EVA statements allow the business to take decisions about those projects that have to be accepted by the business. EVA statements would accept those projects that give the business a chance to experience growth and that add to the value the business. However, the financial managers will not accept those projects that seem to bring less benefit to the business and its value, no matter how much financial gain that project may bring. Although it may seem that the EVA statements neglect the financial figures, the concept is simple which suggests that decisions should be taken on account of the business’s financial health, and not taking those decisions that may financially hurt the business. EVA statements are greatly used to improve the business’s financial statement reporting, results and the future success. It allows the business to take decisions that are beneficial for the business financial position. Moreover, it allows the financial managers to evaluate the financial results in relation to

Comparing Hobbes, Locke and Rousseau Essay Example | Topics and Well Written Essays - 1000 words

Comparing Hobbes, Locke and Rousseau - Essay Example One of the key problems involved in the debate on justification of political authority is the balance between limitations imposed by any political authority and individual freedom. On the one hand, freedom is exceptionally important to the life of a person in many senses. On the other hand, an individual can not be allowed to act solely at his or her will: there must be certain rules for behavior. Establishing this balance between individual freedom and interests of the community is the key task of any state and government which acts like a stabilizer. In case this balance is in place, the highest level of individual freedom is achieved while the risk of falling into total anarchy is avoided (Popper, 1985). According to Thomas Hobbes, in prehistoric uncivilized times before any sort of government emerged, there was constant war with â€Å"every man, against every man† (Hobbes, 1668, p.12). Consequently, Hobbesian justification of authority logically followed from the total brutality of human beings in their natural state characterized by intolerance: submission to authority was the only way to eliminate the brutality and intolerance of the State of Nature (Hobbes, 1668). By contrast, John Locke believed that the original state of man was not as hostile as Hobbes thought. In Locke’s opinion happiness, reason and tolerance were the core characteristics of the natural man, and all humans, in their original state, were equal and absolutely free to pursue things, considered as indisputable rights, namely â€Å"†¦life, health, liberty and possessions† (Locke, 1990, par. 6). However, Locke’s State of Nature is not chaotic with every individual pursuing its own egoistic goals. Despite absence of any authority or government with the power to punish the subjects for wrong actions, Locke believed that the State of Nature was effectively regulated by morality. Since all human beings in the

Sustainability Assignment Example | Topics and Well Written Essays - 2000 words - 1

Sustainability - Assignment Example Sustainability has appeared as a consequence of significant apprehensions about the unplanned social, ecological, and economic penalties of rapid populace growth, economic developments and expenditure of our natural possessions. In its untimely years, EPA acted principally as the country’s ecological watchdog, determined to make certain that businesses met lawful requirements to manage pollution. In succeeding years, EPA started to establish hypothesis, tools, and performances that facilitated it to emerge from scheming pollution to averting it (Anink, Chiel and John 240). Nowadays EPA intends to put sustainability the next intensity of environmental fortification by drawing on progresses in science and expertise to guard human healthiness and the surroundings, and promoting inventive green business applications. As population increases, civilization ought to establish traditions to expand devoid of depleting resources permitting subsequent generations to exist comfortably. Green construction and building is a thought developing from this necessity. One idea of green construction is sustainable building (BragancÃŒ §a, 45). This is an increasing eco-friendly technique of construction proposed to reduce unconstructive impact on the surroundings all through the construction process and organization of life cycle. Obtaining sustainable developments requires strict harmonization from the designers, engineers, and proprietors. The course starts with establishing a location that fits the implementation of the project. Throughout construction, there is alteration to the adjacent ecology there earlier. Excellent planning could decrease the consequences of emergent land. Architects utilize innate resources to diminish damage to surroundings. The solar system and the air current could be power resource s in a house. Experts in air conditioning, water, and thermo electricity set up systems to decrease energy use (Calkins,45).

A Symbolic Look at Hillary Rodham Clinton Essay Example | Topics and Well Written Essays - 750 words

A Symbolic Look at Hillary Rodham Clinton - Essay Example There are some who fear strong woman, while there are also those who revere them. The question is should someone like Hillary Rodham Clinton be celebrated for her intellect and accomplishments, or should she not and for whatever reason Mrs. Clinton for arguments sake is a very strong willed and determined person who knows what she wants, and knows how to get it. In reading personal biographies of her it can be assessed that she came from a strict upbringing in Chicago, and would ultimately finish out her education at Yale Law school where she would meet the future President of the United States William J. Clinton. Ms. Rodham at the time was probably what you would have called a 'traditional Yankee', while her soon to be husband was what most would call a "southern boy". Both exhibiting strong brains and wills, these two would join together and form one of the most powerful political relationships in modern history. During the course of their marriage Mrs. Clinton would stand by her husband as he served as such things like Governor of Arkansas, and then the ultimate prize of 1600 Pennsylvania Avenue. Observers of Hillary can note that the most important role to her is that of mother to their daughter Chelsea who tu rned 25 in February of 2005. Mrs. Clinton has come to be known for her positives, as well as her negatives. Mot notably being the failed health care package that her husband had put her in charge of in 1994 to get it passed through Congress. As most know, it not only did not pass through Congress, but it also gave the members of the Republican party enough ammunition to sail through the midterm elections that year, and retake control of both the House and the Senate. Hillary Clinton is symbolic in that she also reaches out there, often times risking her own credibility, in order to see something succeed. She stuck her neck out as well during the 2000 Senate race in New York when the GOP took advantage of the "carpet bagger" moniker, and tried to use it against Mrs. Clinton to their full advantage. She of course would end up victorious, and continues to serve the state of New York until her term is up in 2006, and has given all inclination that she will seek another term. To be someone that would be considered to be symbolic, they would have to be a person who through action separates themselves from those around them in a notable way. Someone whose actions clearly distinguish themselves from others due to their nature, and the nature in which the perpetrator went about perpetrating the action. Their action(s) prove as a symbol for which they are as a person, and what they stand for on any given issue. Along with her fellow First Lady's, Mrs. Clinton is immortalized through the White House's database of biographies for both the Presidents and their wives. In her biography, the author writes of Mrs. Clinton that, "As the nation's First Lady, Hillary continued to balance public service with private life. Her active role began in 1993 when the President asked her to chair the Task Force on National Health Care Reform. She continued to be a leading advocate for expanding health insurance coverage, ensuring children are properly immunized, and raising public awareness of health issues. She wrote a weekly newspaper column entitled "Talking It Over," which focused on her experiences as First Lady and her observations of women, children, and families she has met around the world. Her 1996 book It

Porter’s Five Forces Analysis Essay Example for Free

Porter’s Five Forces Analysis Essay Porter’s Five Forces Analysis Michael Porter provided a framework that analyses an industry as being influenced by five forces. It has been suggested that management, attempting to establish a competitive marketing advantage over rivals, can use this model to understand the industry context in which the business operates and take appropriate strategic decisions. Threat of entry This means the ease with which other firms can join the industry and compete with existing businesses. The threat of entry is greatest when: economies of scale are low in the industry technology needed to enter the industry is relatively cheap istribution channels are easy to access, e. g. retail shops are not owned by existing manufacturers in the industry there are no legal or patent restrictions on entry The importance of product differentiation is low, so extensive advertising may not be required to get established. The power of buyers This refers to the power that customers have on the producing industry. For example, if there are four major supermarket groups that dominate this sector of retailing, their buyer power over food and other producers will be great. Buyer power will also be increased when: here are many undifferentiated small supplying firms, e. g. many small farmers supplying milk or chicken to large supermarket businesses the cost of switching suppliers is low Buyers can realistically and easily buy from other suppliers. The power of suppliers Suppliers will be relatively powerful compared with buyers when: the cost of switching is high, e. g. from PC computers to AppleMacs When the brand being sold is very powerful and well known, e. g. Cadbury’s chocolate or Nike shoes. Suppliers could realistically threaten to open their own forward-integration operations, e. g. offee suppliers open their own cafes. Customers have little bargaining power as they are small firms and fragmented, e. g. dispersed around the country as with independent petrol stations. The threat of substitutes In Porter’s model, ‘substitute products’ does not mean alternatives in the same industry such as Toyota for Honda cars. It refers to substitute products in other industries. For instance, the demand for aluminum for cans is partly affected by the price of glass for bottling and plastic for containers. These are substitutes for aluminum, but they are not rivals in the same industry. Competitive rivalry This is the key part of this analysis – it sums up the most important factors that determine the level of competition or rivalry in an industry. It is based on the other four forces which are why it is often illustrated in the center of the Five Forces diagram. Competitive rivalry is most likely to be high where: it is cheap and easy for new firms to enter an industry there is a threat from substitute products suppliers have much power Buyers have much power. Reference: http://classof1. com/homework-help/earth-science-homework-help/